Applied Science for Medicine Risk factors for vertically acquired bacterial sepsis Congenital infections (TORCHHS; toxoplasmosis, rubella, cytomegalovirus (CMV), HIV, herpes simplex virus, syphilis) and perinatally acquired infections Risk of serious sepsis across differing paediatric age groups Most common bacterial pathogens causing infection in neonates and maternal sepsis Pharmacokinetics, pharmacodynamics and side effects of antibiotics in neonates and children using beta-lactams and aminoglycosides as examples Glucose homeostasis in fetus and newborn harmacology of acyclovir |
Clinical and Communication Skills Newborn examination; recognition of the seriously unwell infant Basic resuscitation infant/neonate Obtain antenatal history (maternal infective diseases) Review newborn record to obtain information about labour and delivery (note administration of antibiotics to mother in labour, duration of ruptured membranes, presence of maternal fever, use of vitamin K in the newborn) Use of pulse oximetry Recognition of signs of congenital infection Perform and interpret a septic screen (full blood count, blood culture, urine microscopy and culture, lumbar puncture, chest X-ray) Knowledge about the steps required to collect blood, urine and cerebrospinal fluid samples in a sterile fashion; securing intravenous access in neonate; umbilical vessel anatomy and access Initiate appropriate antibiotic therapy Calculate appropriate drug doses for individual patients by weight and body surface area Knowledge of treatments of congenital infection (toxoplasmosis, CMV, HIV) Recognition and management of hypoglycemia of the newborn
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